DONATE
FOR PHYSICIANS
HEALTH AND NUTRITION
ETHICAL RESEARCH & EDUCATION
MEDIA CENTER
LEGISLATIVE FOCUS
CLINICAL RESEARCH
EDUCATIONAL LITERATURE
MEMBERSHIP
SHOP

Connect with Us

 

 

The Physicians Committee



BREAKING RESEARCH NEWS February 2, 2015

Hundreds of Diabetes Studies in Mice Misinterpreted

February 2, 2015

leptin-in-rodent-modelsExpression of human growth hormone in diabetes mouse models could distort study results, according to a new publication in Cell Metabolism.

The authors report that nonpregnant mice experienced changes that typically occur during pregnancy, leading to cellular changes in the pancreas and unexpected insulin production. As a result, hundreds of diabetes studies may have been misinterpreted. This study highlights the limitations of animal models of human diseases such as diabetes.

Brouwers B, de Faudeur G, Osipovich AB, et al. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metab. 2014;20:979-990.

 

Subscribe to the Physicians Committee’s Breaking Research News.

Breaking Research News is a service of the Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave., Ste. 400, Washington, DC 20016, 202-686-2210. Join the Physicians Committee and receive the quarterly magazine, Good Medicine.



Human Organs-on-Chips: Tailoring Testing and Treatments

Technique for Studying Human Genes Improves Disease Research


2015 Archive

2014 Archive

This site does not provide medical or legal advice. This Web site is for informational purposes only.
Full Disclaimer | Privacy Policy

The Physicians Committee
5100 Wisconsin Ave., N.W., Ste.400, Washington DC, 20016
Phone: 202-686-2210     Email: pcrm@pcrm.org