Human-Focused Research Framework to Advance Type 2 Diabetes Research

Paper in a Sentence: Using animal models for researching type 2 diabetes mellitus (T2DM) impedes scientific breakthroughs about the disease origins and treatment options. Researchers recently proposed a human-centered research framework to study the biology of sugar metabolism in humans from molecules to population studies by utilizing novel human-based research technologies such as organ-on-chips and computer simulations.

Healthy for Humans: This human-relevant framework, which incorporates in human cells and tissues and computer modeling technologies, holds great promise to advance the current prevention, diagnosis, and treatment of T2DM in humans.

Redefining Research: Adopting this human-focused research framework may help produce results more relevant to human physiology and overcome translational barriers in diabetes research.