New Human Skin Model to Assess Dermal Sensitivity

Traditional tests for skin sensitization of chemical compounds have relied heavily on the use of animals. A group of scientists has recently tested 10 known skin sensitizers (i.e., compounds causing skin irritation, inflammation, and itchiness) using a nonanimal, human skin cell model called EpiDerm™ tissue. Scientists have analyzed the effects of these compounds by using a specific in vitro test (SenCeeTox® assay) measuring different parameters, such as viability, reactivity, and specific gene expression. Their promising data indicate that this human skin model, in combination with the in vitro assay, may represent a valuable alternative to the use of animals to test medical device extracts.