A Novel Model Will Help Investigate Neuronal Connectivity In Vitro

Modeling the complex neuronal interconnections found in the human brain in vitro is a challenging task. But recently, a group of scientists have been able to successfully culture in vitro different neuronal cell types, forming complex brain structures. In particular, neurons of the neocortex and the midbrain (two different brain regions) have been obtained from human pluripotent stem cells (unspecialized cells) and cultured inside two individual micro-chambers separated by a barrier. Upon removal of the barrier, neurons were able to form connections and synapses. This new in vitro model will help get insights into several neuronal-related diseases, such as schizophrenia, Parkinson's disease, and possibly eating disorders.