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Hundreds of Diabetes Studies in Mice Misinterpreted
Expression of human growth hormone in diabetes mouse models could distort study results, according to a new publication in Cell Metabolism.
The authors report that nonpregnant mice experienced changes that typically occur during pregnancy, leading to cellular changes in the pancreas and unexpected insulin production. As a result, hundreds of diabetes studies may have been misinterpreted. This study highlights the limitations of animal models of human diseases such as diabetes.
References
- Brouwers B, de Faudeur G, Osipovich AB, et al. Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression. Cell Metab. 2014;20:979-990.
