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Recommended Readings for Students and Emerging Scientists
- 3-D Bioprinting Technologies in Tissue Engineering and Regenerative Medicine: Current and Future Trends
Bishop ES, Mostafa S, Pakvasa M, Luu HH, Lee MJ, Wolf JM, et al. Genes & Diseases. 2017. https://doi.org/10.1016/j.gendis.2017.10.002
An overview of 3D bioprinting technology that discusses key advances, clinical applications, current limitations, and the future potential that bioprinting could have in personalized medicine. - Animal Experimentation: Working Towards a Paradigm Change
Herrmann K, Jayne K. Brill, 2019.
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science. - Better Ways to Do Research: An Overview of Methods and Technologies that Can Replace Animals in Biomedical Research and Testing
Merkes M. Humane Research Australia. 2019. doi: 10.13140/RG.2.2.34046.64324
An overview of methods and technologies that can replace the use of animals in biomedical research, testing, education, and training. The article outlines diverse methods and technologies, provides examples for their use, and suggests areas of research, testing, and education where they can replace animals. - Exploring New Technologies in Biomedical Research
Benam KH, Gilchrist S, Kleensang A, Satz AB, Willett C, Zhang Q, et al. Drug Discovery Today. 2019.
https://doi.org/10.1016/j.drudis.2019.04.001
A workshop report that discusses new technologies using human-based in silico and in vitro models for drug and device discovery. - Fallacies of Mice Experiments
De Schutter E. Neuroinformatics. 2019. https://doi.org/10.1007/s12021-019-09420-3
A commentary that calls for experimental neuroscientists to more rigorously justify the necessity and relevance of their work; demonstrates that experimental neuroscience studies using mice are not held to the same rigorous standards as human studies. - Induced Pluripotent Stem Cell Technology: A Decade of Progress
Shi Y, Inoue H, Wu JC, Yamanaka S. Nature Reviews Drug Discovery. 2017.
https://doi.org/10.1038/nrd.2016.245
A review on the progress in applications of iPSC technology relevant to drug discovery and regenerative medicine, and analyzes the remaining challenges and emerging opportunities in the field. - Organoids-on-a-Chip
Park SE, Georgescu A, Huh D. Science. 2019. doi: 10.1126/science.aaw7894
A review of organ-on-a-chip technology as a platform to study biomedicine and examines how it may be leveraged to address major technical challenges in organoid research. This article discusses emerging opportunities and future hurdles for the development and application of organoid-on-a-chip technology. - Rebooting Human Immunology
Davis MM, Brodin P. Annual Review of Immunology. 2018. https://doi.org/10.1146/annurev-immunol-042617-053206
A review of the recent progress in conceptual and technological approaches to the field of human immunology. This paper proposes this progress is critical for the clinical relevance and discovery of new genetic and environmental influences on the immune system that are not seen in mice. - The Rise and Fall of Animal Experimentation: Empathy, Science, and the Future of Research
Miller RJ. Oxford University Press, 2023.
Written by a scientist with over 40 years of laboratory experience, The Rise and Fall of Animal Experimentation critically examines this assumption and asks whether it is true that animal-based research achieves its aims and, if so, how often this occurs and if there are alternatives to performing animal-based science. The book takes readers through the history of animal experimentation: its early beginnings in antiquity, how it advanced in the seventeenth century during the Scientific Revolution until the present day, and explores the diverse scientific, theological, and philosophical influences that formed the basis for these ideas about animal-based science. Referencing developments in various fields including stem cell biology, genetic sequencing, and live imaging, the book describes the scientific advancements that bring the value of animal experimentation into question and encourages biomedical research to consider more anthropocentric paradigms that reflect the entire spectrum of human diversity. - Towards a 21st-Century Roadmap for Biomedical Research and Drug Discovery: Consensus Report and Recommendations
Langley GR, Adcock IM, Busquet F, Crofton KM, Csernok E, Giese C, et al. Drug Discovery Today. 2017. https://doi.org/10.1016/j.drudis.2016.10.011
A consensus report from an international workshop showcasing recommendations to apply human biology-based models and tools to better understand human diseases pathways.
