Animal Experimentation: Working Towards a Paradigm Change Herrmann K, Jayne K. Brill, 2019. Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Fallacies of Mice Experiments De Schutter E. Neuroinformatics. 2019. https://doi.org/10.1007/s12021-019-09420-3 A commentary that calls for experimental neuroscientists to more rigorously justify the necessity and relevance of their work; demonstrates that experimental neuroscience studies using mice are not held to the same rigorous standards as human studies.
Organoids-on-a-Chip Park SE, Georgescu A, Huh D. Science. 2019. doi: 10.1126/science.aaw7894 A review of organ-on-a-chip technology as a platform to study biomedicine and examines how it may be leveraged to address major technical challenges in organoid research. This article discusses emerging opportunities and future hurdles for the development and application of organoid-on-a-chip technology.
Rebooting Human Immunology Davis MM, Brodin P. Annual Review of Immunology. 2018. https://doi.org/10.1146/annurev-immunol-042617-053206 A review of the recent progress in conceptual and technological approaches to the field of human immunology. This paper proposes this progress is critical for the clinical relevance and discovery of new genetic and environmental influences on the immune system that are not seen in mice.
The Rise and Fall of Animal Experimentation: Empathy, Science, and the Future of Research Miller RJ. Oxford University Press, 2023. Written by a scientist with over 40 years of laboratory experience, The Rise and Fall of Animal Experimentation critically examines this assumption and asks whether it is true that animal-based research achieves its aims and, if so, how often this occurs and if there are alternatives to performing animal-based science. The book takes readers through the history of animal experimentation: its early beginnings in antiquity, how it advanced in the seventeenth century during the Scientific Revolution until the present day, and explores the diverse scientific, theological, and philosophical influences that formed the basis for these ideas about animal-based science. Referencing developments in various fields including stem cell biology, genetic sequencing, and live imaging, the book describes the scientific advancements that bring the value of animal experimentation into question and encourages biomedical research to consider more anthropocentric paradigms that reflect the entire spectrum of human diversity.
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